Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 86589966, compound

HRID 984417Notes

Reaction equation

HRID 984417 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[CH2:23][OH:24])=[CH:17][CH:16]=2)[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:25]([O:27][C@@H:28]([CH2:34][C:35]1[CH:40]=[CH:39][C:38](O)=[CH:37][CH:36]=1)[C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH3:26]>>[C:11]([C:9]1[CH:8]=[C:7]([C:15]2[CH:16]=[CH:17][C:18](/[CH:21]=[CH:22]/[CH2:23][O:24][C:38]3[CH:37]=[CH:36][C:35]([CH2:34][C@H:28]([O:27][CH2:25][CH3:26])[C:29]([O:31][CH2:32][CH3:33])=[O:30])=[CH:40][CH:39]=3)=[CH:19][CH:20]=2)[CH:6]=[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])[CH:10]=1)([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 22557673HCID 22557673, compound

Product 1

HCID 86589966HCID 86589966, compoundYield 52%

Procedure

The title compound (110 mg, 51%) was prepared as a colourless gum from (E)-3-(3′,5′-di-tert-butyl-biphenyl-4-yl)-prop-2-en-1-ol (127 mg, 0.39 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (99 mg, 0.41 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-79bdc74a841949f0a5b9efab597df4cd
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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