Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 86589967, compound

HRID 984420Notes

Reaction equation

HRID 984420 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[CH:19][C:18](/[C:21](/[CH3:25])=[CH:22]/[CH2:23][OH:24])=[CH:17][CH:16]=2)[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:26]([O:28][C@@H:29]([CH2:35][C:36]1[CH:41]=[CH:40][C:39](O)=[CH:38][CH:37]=1)[C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH3:27]>>[C:1]([C:5]1[CH:6]=[C:7]([C:15]2[CH:16]=[CH:17][C:18](/[C:21](/[CH3:25])=[CH:22]/[CH2:23][O:24][C:39]3[CH:38]=[CH:37][C:36]([CH2:35][C@H:29]([O:28][CH2:26][CH3:27])[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:41][CH:40]=3)=[CH:19][CH:20]=2)[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 69802680HCID 69802680, compound

Product 1

HCID 86589967HCID 86589967, compoundYield 74.1%

Procedure

The title compound (429 mg, 74%) was prepared as a colourless gum from (E)-3-(3′,5′-di-tert-butyl-biphenyl-4-yl)-but-2-en-1-ol (350 mg, 1.04 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (260 mg, 1.09 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-073f1e2b041a467db4aba35ba471f97f
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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