4-Fluorophenylboronic acid → (E)-ethyl 3-(4'-fluoro-biphenyl-4-yl)-but-2-enoate

HRID 984423Notes

Reaction equation

HRID 984423 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5](/[C:8](/[CH3:15])=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[CH:7]=[CH:6][C:5](/[C:8](/[CH3:15])=[CH:9]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 11438459(E)-ethyl 3-(4-iodophenyl)-but-2-enoate

Product 1

HCID 22557664(E)-ethyl 3-(4'-fluoro-biphenyl-4-yl)-but-2-enoate

Procedure

The colourless solid (E)-ethyl 3-(4′-fluoro-biphenyl-4-yl)-but-2-enoate was prepared from (E)-ethyl 3-(4-iodophenyl)-but-2-enoate (example 91 a) and 4-fluorobenzene boronic acid by a procedure analogous to that described in example 52a.

Sources & evidence

ORD record
ord-7df931eeea0a4dbeb00b719876ca0ab7
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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