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2-Chlorobenzaldehyde → (2-Bromophenyl)[2-chloro-4-(E-((4-acetylhomopiperazin-1-yl)carbonyl) ethenyl)phenyl]sulfide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chlorobenzaldehyde | HCID 6996 | — |
| 反応物 | 6-Amino-1-hexanol | HCID 19960 | — |
| 反応物 | 2,4-Dichlorobenzenethiol | HCID 70730 | — |
| 反応物 | 2-Bromobenzenethiol | HCID 80598 | — |
| 反応物 | 3-Chloro-4-fluorobenzaldehyde | HCID 593866 | — |
| 反応物 | N-Acetylhomopiperazine | HCID 4186202 | — |
| 生成物 | (2-Bromophenyl)[2-chloro-4-(E-((4-acetylhomopiperazin-1-yl)carbonyl) ethenyl)phenyl]sulfide | HCID 9805756 | — |
反応手順
The title compound was prepared by the procedures described in Example 1 substituting 2,4-dichlorothiophenol with 2-bromothiophenol, 2-chlorobenzaldehyde with 3-chloro-4-fluoro-benzaldehyde, and 6-amino-1-hexanol with 4-acetylhomopiperazine. 1H NMR (DMSO-d6, 300 MHz) δ 8.10 (m, 1H), 7.81 (d, J=7.7 Hz, 1H), 7.64 (m, 1H), 7.24-7.51 (m, 5H), 7.05 (m, 1H), 3.39-3.77 (m, 8H), 1.97 (m, 3H), 1.68 (m, 2H). HRMS calculated for C22H22N2O2S1Br1Cl1: 493.0352. Observed: 493.0352.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06867203B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-6cfc7eeaddbd4060b1b42150ac8e0929 |
| 出典メモ | uspto-grants-2005_03 |