HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Methyl-2,3-bis(trifluoromethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Methyl-2,3-bis(trifluoromethyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene | HCID 13294464 | — |
| Product | 4-Methyl-2,3-bis(trifluoromethyl)phenol | HCID 10847856 | 85.2% |
Reaction Steps
A mixture of Example 359A (12.0 g, 0.05 mol) and boron trifluoride-diethyl ether complex (150 mL) was stirred at room temp overnight, then neutralized carefully with 20% aqueous potassium carbonate, then the mixture was extracted with ether. The ether layer was dried over MgSO4 and evaporated under reduced pressure to afford 10.4 g (85%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06867203B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-8a1cc88a40e040aab1c642ee4a1d2d66 |
| Source note | uspto-grants-2005_03 |