Sulfuric Acid → 4-Phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid

Participants

Reaction Steps

4-Cyano-4-phenylpiperidine hydrochloride (2.0 g, 0.11 mol) was dissolved in 8 mL of conc. H2SO4 and 4 mL of H2O, then the solution was heated at reflux for 4 h. The solution was cooled and then NaOH was added to precipitate a white solid. The solid was collected, then dissolved in methanol, and the solution was filtered and concentrated to obtain a white solid. This dried solid was used without purification for Example 385B.

Provenance & Evidence