HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodonaphthalene → Naphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodonaphthalene | HCID 7004 | — |
| Reactant | Hexane | HCID 8058 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | Naphthalene | HCID 931 | 30% |
Reaction Steps
Following General Procedure I, a mixture of hexane washed KH (160 mg, 4.0 mmol, 2.0 equiv), (Z)-21 (344 mg, 2.0 mmol, 1.0 equiv), 1-iodonaphthalene (292 μL, 2.0 mmol) and Pd(dba)2 (58 mg, 0.1 mmol, 0.05 equiv) was stirred in DME (4 mL) at room temperature for 15 min, and then was filtered through SiO2. Purification by column chromatography (RP C18, MeOH/H2O, 9/1) afforded 219 mg (49%) of (Z)-152a and 77 mg (30%) of naphthalene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06867323B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-604c957b1eca40e79807a170af418ecb |
| Source note | uspto-grants-2005_03 |