1-Iodonaphthalene → HCID 11379100, compound

Participants

Reaction Steps

Following General Procedure II, a mixture of KOSiMe3 (570 mg, 4.0 mmol, 2.0 equiv), (E)-21 (379 mg, 2.2 mmol, 1.1 equiv), 1-iodonaphthalene (292 μL, 2.0 mmol) and Pd(dba) (58 mg, 0.1 mmol, 0.05 equiv) was stirred at room temperature for 2 h, and then was filtered through SiO2. Purification by column chromatography (RP C18, MeOH/H2O, 9/1) and Kugelrohr distillation afforded 416 mg (93%) of (E)-154a as colorless oil.

Provenance & Evidence