Ethyl 4-iodobenzoate → HCID 11160945, compound

Participants

Reaction Steps

Following General Procedure II, a mixture of KOSiMe3 (570 mg, 4.0 mmol, 2.0 equiv), (E)-21 (379 mg, 2.2 mmol, 1.1 equiv), ethyl-4-iodobenzoate (2.0 mmol) and Pd(dba)2 (58 mg, 0.1 mmol, 0.05 equiv) was stirred at room temperature for 15 min, and then was filtered through SiO2. Purification by column chromatography (SiO2, Hexane/Ethyl Acetate, 50/1) and Kugelrohr distillation afforded 413 mg (84%) of (E)-154f as colorless oil.

Provenance & Evidence