Hexylamine → HCID 9899074, compound

HRID 984671Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[CH2:9]([NH2:15])[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]>>[NH2:15][C:9]1[CH:14]=[C:13]([CH:12]=[CH:11][CH:10]=1)[NH:5][CH2:4][CH2:3][CH2:2][CH2:8][CH2:7][CH3:6]

Participants

Reactant 2

HCID 8102Hexylamine

HCID 115623-Bromoaniline

Product 1

HCID 9899074HCID 9899074, compoundYield 80.1%

Procedure

Using the general procedure, 3-bromoaniline (172 mg, 1.0 mmol) was coupled with n-hexylamine (198 μL, 1.5 mmol). Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (2:1) as eluent afforded the desired product as a colorless oil (154 mg, 80% yield). Rf=0.4 (hexane/ethyl acetate=2:1).

Workup

customPurification of the crude product by column chromatography on silica gel

Sources & evidence

ORD record: ord-77633c5869f448459cf4c0fdc7115c11
Source dataset: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06867298B2

Reaction notes

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