참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dodecane | HCID 8182 | — |
| 반응물 | N-Methylformamide | HCID 31254 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 1-Iodo-3,5-dimethylbenzene | HCID 140924 | — |
| 반응물 | HCID 178454901 | HCID 178454901 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(3,5-dimethylphenyl)-N-methylformamide | HCID 9855564 | 46% |
반응 단계
A Schlenk tube was charged with CuI (9.6 mg, 0.050 mmol, 5.0 mol %), di-tert-butylphosphine oxide (16.5 mg, 0.102 mmol), K3PO4 (430 mg, 2.03 mmol), evacuated, backfilled with Ar. 5-Iodo-m-xylene (145 μL, 1.00 mmol), N-methylformamide (72 μL, 1.23 mmol), and toluene (1.0 mL) were added under Ar. The Schlenk tube was sealed with a Teflon valve and the reaction mixture was stirred at 110° C. for 24 h. The suspension was allowed to reach room temperature. Dodecane (internal GC standard, 230 μL) and ethyl acetate (2 mL) were added. A 0.1 mL sample of the supernatant solution was diluted with ethyl acetate (1 mL) and analyzed by GC to provide a 46% yield of N-(3,5-dimethylphenyl)-N-methylformamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06867298B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_03 |
|---|
| ORD ID | ord-08b3a357a805443f814394c8feec43ff |
|---|
| 출처 메모 | uspto-grants-2005_03 |
|---|
