N-bromobutanimide → HCID 22559011, compound

HRID 984700Notes

Reaction equation

HRID 984700 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:5][CH:4]=1.C1C(=O)N([Br:22])C(=O)C1>>[Br:22][C:8]1[CH:7]=[C:6]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:4][C:3]=1[O:2][CH3:1]

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 782804-(4-Methoxyphenyl)butyric acid

Product 1

HCID 22559011HCID 22559011, compoundYield 99.6%

Procedure

According to the procedure described in the synthesis method of Intermediate 3 in Reference Example 1 (Step g) with the modifications that the reaction was carried out under ice cooling for 30 minutes and at room temperature for 20 hours, 4-(4-methoxyphenyl)butyric acid (11.64 g, Ald) and NBS (11.21 g) were reacted and treated to obtain the title compound (Intermediate 11, 16.30 g).

Workup

  1. additiontreated

Sources & evidence

ORD record
ord-4afe830a93d54039abe399b2cbed8008
Source dataset
uspto-grants-2005_03
Patent number
US06867320B2

Reaction notes

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