2,5-Dibromopyridine → 2-(Benzofuran-2-yl)-5-(thiophene-3-yl)pyridine

Participants

Role	Name	HCID	Charge
Reactant	2,5-Dibromopyridine	HCID 69353	—
Reactant	Thiophene-3-boronic acid	HCID 581760	—
Reactant	Benzo[b]furan-2-boronic acid	HCID 2776266	—
Reactant	2-(Benzofuran-2-yl)-5-bromopyridine	HCID 22508335	—
Product	2-(Benzofuran-2-yl)-5-(thiophene-3-yl)pyridine	HCID 22508334	—

Reaction Steps

It is easy to synthesis the following compound in the same manner as in Example 1 except that 2-(benzofuran-2-yl)-5-bromopyridine was synthesized from 2,5-dibromopyridine (made by Tokyo Kasei Kogyo K.K.) and 2-benzofuranboronic acid (made by Aldrich Co.) and is reacted with 3-thiopheneboronic acid (made by Aldrich Co.) to obtain 2-(benzofuran-2-yl)-5-(thiophene-3-yl)pyridine, which is used instead of 2-(5-trifluoromethylpyridine-2-yl)benzofuran.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06869694B2
Source dataset	uspto-grants-2005_03
ORD ID	ord-c81d8596b33545ada16eb903414ed77a
Source note	uspto-grants-2005_03