N,N-Dimethylaniline → 2,3-Dimethyl-5,12-dihydrobenzo[b]phenazine

HRID 984759Notes

Reaction equation

HRID 984759 reaction equation
O[C:2]1[C:11](O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[CH3:13][C:14]1[C:19]([CH3:20])=[CH:18][C:17]([NH2:21])=[C:16]([NH2:22])[CH:15]=1.CN(C)C1C=CC=CC=1.C(Cl)Cl>C1(C)C=CC=CC=1.CCCCCCC>[CH3:13][C:14]1[C:19]([CH3:20])=[CH:18][C:17]2[NH:21][C:2]3[CH:3]=[C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:9]4=[CH:10][C:11]=3[NH:22][C:16]=2[CH:15]=1

Participants

7

Reactant 4

HCID 949N,N-DimethylanilineHCID 6344DichloromethaneHCID 70912,3-Dihydroxynaphthalene2×HCID 766354,5-Dimethyl-1,2-phenylenediamine

Product 1

HCID 222514692,3-Dimethyl-5,12-dihydrobenzo[b]phenazineYield 33%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8900HeptaneSolvent

Procedure

2,3-dihydroxynapthalene (10 g, 62.5 mmol), 4,5-dimethyl-1,2-phenylenediamine (8.5 g, 62.5 mmol) and N,N-dimethylaniline (54 ml) are placed into a round bottom flask under nitrogen atmosphere. Mixture is stirred at reflux. Reaction is monitored by TLC (CH2Cl2:Heptane/1:1) until all 2,3-dihydroxynaphthalene has reacted (˜3 hours). After cooling to room temperature, toluene (100 ml) is added and solid is collected by vacuum filtration. After washing with toluene (50 ml), ethanol (100 ml) and hexanes (50 ml), the product is dried under vacuum to yield 23.3 g (33% yield) of light yellow solid.

Workup

  1. temperatureat reflux
  2. customReaction
  3. customhas reacted (˜3 hours)
  4. filtrationsolid is collected by vacuum filtration
  5. washAfter washing with toluene (50 ml), ethanol (100 ml) and hexanes (50 ml)
  6. customthe product is dried under vacuum
  7. customto yield 23.3 g (33% yield) of light yellow solid

Sources & evidence

ORD record
ord-a7a4d4dccd7b4790bb772af91fb75133
Source dataset
uspto-grants-2005_03
Patent number
US06869699B2

Reaction notes

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