Hydrochloric Acid → 1-(2,4-Dichlorobenzyl)-6-ethoxycarbonyl-2-methylbenzimidazole

Participants

Reaction Steps

A mixture of 250 g of ethyl 4-(acetylamino)-3-((2,4-dichlorobenzyl)amino)benzoate, 68.4 g of concentrated hydrochloric acid, and 1197 g of ethanol was refluxed for 2 hours, to give 1-(2,4-dichlorobenzyl)-6-(ethoxycarbonyl)-2-methylbenzimidazole. To this reaction solution, a solution consisting of 105 g of sodium hydroxide and 1000 g of water was added, and the reaction solution was refluxed for 2 hours. The reaction solution was cooled, and was neutralized with the slow addition of 193.3 g of concentrated hydrochloric acid. The crystals precipitated were separated through filtration, were washed with 900 ml of a mixed solution of ethanol and water at a ratio of 2:1, and were dried to give 214 g of the title compound.

Provenance & Evidence