Ethanol → HCID 10207974, compound

Participants

Reaction Steps

3-{3-[3,3-Bis-(4-bromo-phenyl)-allyloxy]-phenyl}-propionic acid ethyl ester (example 1) (755 mg, 1.4 mmol) was hydrolysed in 1N NaOH (5.6 ml) and ethanol (15 ml) for 16 h at room temperature. Water (5 ml) was added and ethanol removed by concentration in vacuo. The mixture was neutralised with 6N HCl. The crude product was extracted with ethyl acetate (×3). The organic layers were combined, dried (MgSO4) and evaporated. The residue was dissolved in toluene and the title compound precipitated with petroleum ether, to give 430 mg of the title compound.

Provenance & Evidence