Water → HCID 10295840, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (E)-{4-[3-(4-bromo-phenyl)-3-phenyl-allyloxy]-phenyl}-acetic acid ethyl ester (example 11) (700 mg, 1.6 mmol) in THF (5 m) and ethanol (5 ml) was added 1N, NaOH (5.0 ml) and the reaction mixture was stirred for 1 h at 60° C. for 1 h and at room temperature over night. The reaction mixture was added water and the organic solvent evaporated. 1 N HCl was added to pH ˜1-2 and the product extracted with dichloromethane/isopropanol (19:1). The combined organic phases were dried (MgSO4), filtered and concentrated in vacuo. The residue was suspended in toluene/petroleum ether (1:1) and 490 mg (70%) of the title compound was isolated by filtration.

Provenance & Evidence