Ethanol → Ethyl 3-chloro-4-hydroxyphenylacetate

Participants

Reaction Steps

To an ice-cooled solution of 3-chloro-4-hydroxyphenyl-acetic acid (10.0 g, 53 mmol) in ethanol was dropwise added thionyl chloride (3.9 mL. 53.5 mmol). The mixture was stirred at room temperature over night, concentrated in vacuo and submitted to flash chromatography (eluent: graduated from 10% ethyl acetate in toluene to toluen) to give 11 g of 3-chloro-4-hydroxyphenyl-acetic acid ethyl ester.

Provenance & Evidence