(Bromomethyl)cyclopentane → 2-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

HRID 985009Notes

Reaction equation

HRID 985009 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]([C:17]([O:19][CH3:20])=[O:18])[C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH:21]1([CH2:26]Br)[CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH:21]1([CH2:26][N:14]2[C:13](=[O:16])[C:12]([C:17]([O:19][CH3:20])=[O:18])=[CH:11][C:10]([C:4]3[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=3)=[N:15]2)[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 12723264(Bromomethyl)cyclopentaneHCID 219914326-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219916512-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneYield 72%

Procedure

Following the procedure of Example 1(6), 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and cyclopentylmethyl bromide {J. Org. Chem., 36, 3103 (1971)} were reacted to yield the title compound as yellow needles (yield: 72.0%).

Workup

  1. custom, 36, 3103 (1971)} were reacted

Sources & evidence

ORD record
ord-98c96e52202b4af88a4e83f91da9efc0
Source dataset
uspto-grants-2005_03
Patent number
US06869954B2

Reaction notes

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