tert-Butyl piperazine-1-carboxylate → HCID 21991703, compound

HRID 985012Notes

Reaction equation

HRID 985012 reaction equation
[CH:1]1([CH2:6][N:7]2[C:12](=[O:13])[C:11]([CH2:14]OS(C)(=O)=O)=[CH:10][C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([F:28])[CH:21]=3)=[N:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:29]1([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[C:38]([O:37][C:35]([N:29]1[CH2:34][CH2:33][N:32]([CH2:14][C:11]2[C:12](=[O:13])[N:7]([CH2:6][CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[N:8]=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([F:28])[CH:21]=3)[CH:10]=2)[CH2:31][CH2:30]1)=[O:36])([CH3:41])([CH3:40])[CH3:39]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 219916532-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methanes ulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 21991703HCID 21991703, compoundYield 78.8%

Procedure

Following the procedure of Example 1(10), 2-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted to yield the title compound as a yellow oil (yield: 78.8%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b78794112af8499d8ae2631b9109f653
Source dataset
uspto-grants-2005_03
Patent number
US06869954B2

Reaction notes

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