HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonate → 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methoxycarbonyl-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | 3-(4-Fluorophenyl)propan-1-ol | HCID 13747241 | — |
| Reactant | 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991432 | — |
| Product | 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991461 | 90.1% |
Reaction Steps
Following the procedure of Example 1(6), 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and the mesylate derivative of 3-(4-fluorophenyl)-1-propanol {J. Med. Chem., 19, 461 (1976)} were reacted to yield the title compound as a yellow oil (yield: 90.1%). The mesylate derivative was prepared in accordance with the procedure of Example 1(9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06869954B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-9431e402a7224e0e930be68b5a0a6426 |
| Source note | uspto-grants-2005_03 |