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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 985018Generated: October 29, 2026

1-Methylpiperazine → 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

https://huagongshe.com/reaction/985018

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
Reactant6-(3-Fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methanesulfonyloxymethyl-2h-pyridazin-3-oneHCID 21991614—
Product6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneHCID 1018355679.3%

Reaction Steps

Following the procedure of Example 1(10), 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 79.3%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06869954B2
Source datasetuspto-grants-2005_03
ORD IDord-6c5abc3e41be4732ab20a2d1d0e814a7
Source noteuspto-grants-2005_03