tert-Butyl piperazine-1-carboxylate → 4-(4-tert-butoxycarbonyl-1-piperazinyl)methyl-6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-2H-pyridazin-3-one

HRID 985020Notes

Reaction equation

HRID 985020 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]([CH2:27]OS(C)(=O)=O)[C:13](=[O:26])[N:14]([CH2:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[N:15]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[N:33]1([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[C:42]([O:41][C:39]([N:33]1[CH2:38][CH2:37][N:36]([CH2:27][C:12]2[C:13](=[O:26])[N:14]([CH2:16][CH2:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)[N:15]=[C:10]([C:4]3[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=3)[CH:11]=2)[CH2:35][CH2:34]1)=[O:40])([CH3:45])([CH3:43])[CH3:44]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 219916146-(3-Fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methanesulfonyloxymethyl-2h-pyridazin-3-one

Product 1

HCID 219914644-(4-tert-butoxycarbonyl-1-piperazinyl)methyl-6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-2H-pyridazin-3-oneYield 72.6%

Procedure

Following the procedure of Example 1(10), 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted to yield the title compound as a yellow oil (yield: 72.6%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-fa063eb484224bd3b2057f55e75ae54f
Source dataset
uspto-grants-2005_03
Patent number
US06869954B2

Reaction notes

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