Ethyl (4-mercapto-2-methylphenoxy)acetate → (4-Mercapto-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid ethyl ester

HRID 985062Notes

Reaction equation

HRID 985062 reaction equation
C(OC(=O)COC1C=CC(S)=CC=1C)C.[CH2:16]([O:18][C:19](=[O:36])[CH2:20][O:21][C:22]1[C:31]2[CH2:30][CH2:29][CH2:28][CH2:27][C:26]=2[C:25]([S:32](Cl)(=O)=O)=[CH:24][CH:23]=1)[CH3:17]>>[CH2:16]([O:18][C:19](=[O:36])[CH2:20][O:21][C:22]1[C:31]2[CH2:30][CH2:29][CH2:28][CH2:27][C:26]=2[C:25]([SH:32])=[CH:24][CH:23]=1)[CH3:17]

Participants

3

Reactant 2

HCID 16641178Ethyl (4-mercapto-2-methylphenoxy)acetateHCID 20768129(4-Chlorosulfonyl-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid ethyl ester

Product 1

HCID 20768130(4-Mercapto-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid ethyl ester

Procedure

The title compound was prepared according to the method described for preparing compound 10.3, using compound 22.2 as the starting material. 1H NMR (300 MHz) (CDCl3) δ 7.11 (1H, d, J=8.5 Hz); 6.46 (1H, d, J=8.4 Hz); 4.59 (2H, s); 4.26 (2H, q, J=7.1 Hz); 3.10 (1H, s); 2.76-2.65 (4H, m); 1.82-1.74 (4H, m); 1.30 (3H, t, J=7.1 Hz).

Sources & evidence

ORD record
ord-18ed693830164bc6acbff183e7d31a9a
Source dataset
uspto-grants-2005_03
Patent number
US06869975B2

Reaction notes

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