2,5-Dimethyl-4-[[2-methyl-4-[(4-trifluoromethyl-phenylamino)methyl]phenyl]sulfanyl]-phenoxy-acetic acid ethyl ester → (4-{2-Chloro-4-[(4-trifluoromethyl-phenylamino)-methyl]-phenylsulfanyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid ethyl ester

HRID 985064Notes

Reaction equation

HRID 985064 reaction equation
C(OC(=O)COC1C=C(C)C(SC2C=CC(C[NH:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)=CC=2C)=CC=1C)C.[CH2:36]([O:38][C:39](=[O:62])[CH2:40][O:41][C:42]1[C:51]2[CH2:50][CH2:49][CH2:48][CH2:47][C:46]=2[C:45]([S:52][C:53]2[CH:58]=[CH:57][C:56]([CH:59]=O)=[CH:55][C:54]=2[Cl:61])=[CH:44][CH:43]=1)[CH3:37]>>[CH2:36]([O:38][C:39](=[O:62])[CH2:40][O:41][C:42]1[C:51]2[CH2:50][CH2:49][CH2:48][CH2:47][C:46]=2[C:45]([S:52][C:53]2[CH:58]=[CH:57][C:56]([CH2:59][NH:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:30])([F:31])[F:32])=[CH:25][CH:24]=3)=[CH:55][C:54]=2[Cl:61])=[CH:44][CH:43]=1)[CH3:37]

Participants

3

Reactant 2

HCID 207681062,5-Dimethyl-4-[[2-methyl-4-[(4-trifluoromethyl-phenylamino)methyl]phenyl]sulfanyl]-phenoxy-acetic acid ethyl esterHCID 20768127[4-(2-Chloro-4-formyl-phenylsulfanyl)-5,6,7,8-tetrahydro-naphthalen-1-yloxy]-acetic acid ethyl ester

Product 1

HCID 20768126(4-{2-Chloro-4-[(4-trifluoromethyl-phenylamino)-methyl]-phenylsulfanyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid ethyl ester

Procedure

The title compound was prepared according to the method described for preparing compound 21.5, using compound 22.4 as the starting material. 1H NMR (300 MHz) (CDCl3) δ 7.38 (2H, d, J=8.6 Hz); 7.34 (1H, d, J=8.6 Hz); 7.33 (1H, s); 6.99 (1H, dd, J=1.5, 7.9 Hz); 6.58 (3H, d, J=7.1 Hz); 6.49 (1H, d, J=8.2 Hz); 4.67 (2H, s); 4.37 (1H, brt); 4.28 (2H, q, J=7.2 Hz); 4.28 (2H, d, J=4.5 Hz); 2.78-2.74 (4H, m); 1.74-1.72 (4H, m); 1.31 (3H, t, J=7.1 Hz).

Sources & evidence

ORD record
ord-4093917b82fa44c893092a7811c6f440
Source dataset
uspto-grants-2005_03
Patent number
US06869975B2

Reaction notes

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