(4-{2-Chloro-4-[(4-trifluoromethyl-phenylamino)-methyl]-phenylsulfanyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid ethyl ester → (4-{2-Chloro-4-[(4-trifluoromethyl-phenylamino)-methyl]-phenylsulfanyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	(4-{2-Chloro-4-[(4-trifluoromethyl-phenylamino)-methyl]-phenylsulfanyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid ethyl ester	HCID 20768126	—
Reactant	4-[[4-[(4-Trifluoromethylphenoxy)methyl]phenyl]sulfanyl]-2-methylphenoxy-acetic acid	HCID 22555039	—
Product	(4-{2-Chloro-4-[(4-trifluoromethyl-phenylamino)-methyl]-phenylsulfanyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid	HCID 22555031	—

Reaction Steps

The title compound was prepared according to the method described for preparing compound 7, using compound 22.5 as the starting material. MS APSI m/e: 520 (M−H). 1H NMR (400 MHz) (DMSO-d6) δ 13.03 (1H, brs); 7.43 (1H, s); 7.35 (2H, d, J=8.6 Hz); 7.31 (1H, d, J=8.5 Hz); 7.16 (1H, d, J=8.2 Hz); 6.98 (1H, t, J=6.0 Hz); 6.78 (1H, d, J=8.6 Hz); 6.64 (2H, d, J=8.6 Hz); 6.48 (1H, d, J=8.2 Hz); 4.75 (2H, s); 4.26 (2H, d, J=5.9 Hz); 2.66-2.63 (4H, m); 1.66-1.65 (4H, m).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06869975B2
Source dataset	uspto-grants-2005_03
ORD ID	ord-0a8ce070d1634c10a2e8ef4a33748e3d
Source note	uspto-grants-2005_03