4-[[2-Chloro-4-[(4-trifluoromethylphenoxy)methyl]phenyl]sulfanyl]-2-methylphenoxy-acetic acid ethyl ester → {4-[2-Chloro-4-(4-trifluoromethyl-phenoxymethyl)-phenylsulfanyl]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetic acid ethyl ester

HRID 985066Notes

Reaction equation

HRID 985066 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)=[CH:16][C:15]=2[Cl:32])=[CH:9][C:8]=1[CH3:33])[CH3:2].C(OC(=O)CO[C:41]1[C:50]2CCCCC=2C(SC2C=CC(CO)=CC=2Cl)=C[CH:42]=1)C>>[CH2:1]([O:3][C:4](=[O:34])[CH2:5][O:6][C:7]1[C:8]2[CH2:33][CH2:50][CH2:41][CH2:42][C:9]=2[C:10]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:24][CH:23]=3)=[CH:16][C:15]=2[Cl:32])=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 207681144-[[2-Chloro-4-[(4-trifluoromethylphenoxy)methyl]phenyl]sulfanyl]-2-methylphenoxy-acetic acid ethyl esterHCID 20768128[4-(2-Chloro-4-hydroxymethyl-phenylsulfanyl)-5,6,7,8-tetrahydro-naphthalen-1-yloxy]-acetic acid ethyl ester

Product 1

HCID 20768125{4-[2-Chloro-4-(4-trifluoromethyl-phenoxymethyl)-phenylsulfanyl]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetic acid ethyl ester

Procedure

The title compound was prepared according to the method described for preparing compound 10.6, using compound 23.1 as the starting material. 1H NMR (400 MHz) (CDCl3) δ 7.54 (2H, d, J=8.7 Hz); 7.42 (1H, d, J=1.7 Hz); 7.37 (1H, d, J=8.5 Hz); 7.06 (1H, dd, J=1.8, 8.2 Hz); 6.99 (2H, d, J=8.7 Hz); 6.59 (1H, d, J=8.5 Hz); 6.52 (1H, d, J=8.2 Hz); 4.99 (2H, s); 4.68 (2H, s); 4.29 (2H, q, J=7.1 Hz); 2.80-2.73 (4H, m); 1.76-1.70 (4H, m); 1.32 (3H, t, J=7.2 Hz).

Sources & evidence

ORD record
ord-91f68e6dc96949abba96e88f8abfe36d
Source dataset
uspto-grants-2005_03
Patent number
US06869975B2

Reaction notes

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