{4-[2-Chloro-4-(4-trifluoromethyl-phenoxymethyl)-phenylsulfanyl]-2,5-dimethyl-phenoxy}-acetic acid ethyl ester → {4-[2-Chloro-4-(4-trifluoromethyl-phenoxymethyl)-phenylsulfanyl]-2,5-dimethyl-phenoxy}-acetic acid

HRID 985071Notes

Reaction equation

HRID 985071 reaction equation
FC(F)(F)C1C=CC(OCC2C=CC(SC3C=CC(OCC(O)=O)=C(C)C=3)=CC=2)=CC=1.C([O:34][C:35](=[O:66])[CH2:36][O:37][C:38]1[CH:43]=[C:42]([CH3:44])[C:41]([S:45][C:46]2[CH:51]=[CH:50][C:49]([CH2:52][O:53][C:54]3[CH:59]=[CH:58][C:57]([C:60]([F:63])([F:62])[F:61])=[CH:56][CH:55]=3)=[CH:48][C:47]=2[Cl:64])=[CH:40][C:39]=1[CH3:65])C>>[Cl:64][C:47]1[CH:48]=[C:49]([CH2:52][O:53][C:54]2[CH:55]=[CH:56][C:57]([C:60]([F:63])([F:61])[F:62])=[CH:58][CH:59]=2)[CH:50]=[CH:51][C:46]=1[S:45][C:41]1[C:42]([CH3:44])=[CH:43][C:38]([O:37][CH2:36][C:35]([OH:66])=[O:34])=[C:39]([CH3:65])[CH:40]=1

Participants

3

Reactant 2

HCID 20768113{4-[2-Chloro-4-(4-trifluoromethyl-phenoxymethyl)-phenylsulfanyl]-2,5-dimethyl-phenoxy}-acetic acid ethyl esterHCID 225550394-[[4-[(4-Trifluoromethylphenoxy)methyl]phenyl]sulfanyl]-2-methylphenoxy-acetic acid

Product 1

HCID 10141576{4-[2-Chloro-4-(4-trifluoromethyl-phenoxymethyl)-phenylsulfanyl]-2,5-dimethyl-phenoxy}-acetic acid

Procedure

The title compound was prepared according to the method described for preparing compound 7, using compound 24.3 as the starting material. MS APSI m/e: 495 (M−H). 1H NMR (400 MHz) (DMSO-d6) δ 12.97 (1H, brs); 7.66 (2H, d, J=8.8 Hz); 7.59 (1H, d, J=1.5 Hz); 7.35 (1H, s); 7.28 (1H, dd, J=1.4, 8.0 Hz); 7.17 (2H, d, J=8.8 Hz); 6.97 (1H, s); 6.49 (1H, d, J=8.0 Hz); 5.12 (2H, s); 4.78 (2H, s); 2.24 (3H, s); 2.17 (3H, s).

Sources & evidence

ORD record
ord-8a715e1b4fc14873b4aea654be411b4d
Source dataset
uspto-grants-2005_03
Patent number
US06869975B2

Reaction notes

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