Diethylene Glycol Monomethyl Ether → (7S,8R,9R)-8-Hydroxy-7-[2-(2-methoxyethoxy)ethoxy]-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine

Participants

Reaction Steps

350 mg of the title compound are obtained by column chromatographic purification on silica gel (eluent: diethyl ether/2-propanol=10/1) of the crude product from the above reaction of (7R,8R,9R)-7,8-dihydroxy-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine with 2-(2-methoxyethoxy)ethanol. 1H-NMR (200 MHz, DMSO): δ=2.26 (s, 3H), 2.33 (s, 3H), 3.23 (s, 3H), 3.39-4.01 (m, 8H), 3.59-3.69 (m, 2H), 4.25-4.26 (d, 1H), 4.45-4.50 (m, 1H), 4.64-4.68 (d, 1 OH), 5.94-5.95 (d, 1 NH), 6.76-6.79 (d, 1H), 7.24-7.44 (m, 6H).

Provenance & Evidence