Benzenepentanoic acid → HCID 20768294, compound

Participants

Reaction Steps

A solution of 41 (50 mg, 0.170 mmol), 5-phenylvaleric acid (33 mg, 0.187 mmol), 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (36 mg, 0.187 mmol), 1-hydroxy-7-azabenzotriazole (25 mg, 0.187 mmol) in N,N-dimethylformamide was stirred at room temperature for 18 h. The contents of the reaction flask were poured into water and sat. sodium bicarbonate. Extracted with methylene chloride (3×). The combined organic extracts were washed with 5% potassium bisulfate, dried with sodium sulfate (anh.) and filtered. Concentration of the filtrate in vacuo followed by trituration with ether gave 42 as a white solid (62 mg, 140 mmol, 82.1%).

Provenance & Evidence