Hydrochloric Acid → HCID 22555951, compound

Participants

Reaction Steps

A solution of 109 (3.11 g, 9.39 mmol), 6N hydrochloric acid (150 mL), and dioxane (150 mL) was heated at reflux under Ar for 18 h. Acetic acid (50 mL) was added and refluxing was continued for an additional 4 h. The organic solvents were removed in vacuo and the remaining aqueous was extracted with ethyl acetate (3×), washed with brine and dried with sodium sulfate (anh.). Filtration followed by removal of the solvent in vacuo gave 110 as a white solid (1.32 g, 5.16 mmol, 54.9%)

Provenance & Evidence