HOAt → HCID 20768295, compound

Participants

Reaction Steps

A solution of 110 (2.55 g, 9.96 mmol), 111 (2.38 g, 12.0 mmol), 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (2.30 g, 12.0 mmol), 1-hydroxy-7-azabenzotriazole (1.63 g, 12.0 mmol) in N,N-dimethylformamide was stirred at room temperature for 4 days. The contents of the reaction flask were poured into water and sat. sodium bicarbonate. Extracted with methylene chloride (3×). The combined organic extracts were dried with sodium sulfate (anh.) and filtered. Concentration of the filtrate in vacuo followed flash column chromatography (hexane:ethyl acetate 60:40) gave 112 as a white foam (3.16 g, 7.23 mmol, 72.6%).

Provenance & Evidence