HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 6-hydroxy-N,1-dimethylindole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 6-methoxy-N,1-dimethyl-1H-indole-3-carboxamide | HCID 22143490 | — |
| Product | 6-hydroxy-N,1-dimethylindole-3-carboxamide | HCID 23572873 | 51.1% |
Reaction Steps
This material was prepared from 6-methoxy-1-methyl-1H-indole-3-carboxylic acid methylamide 21a (453 mg, 2.1 mmol) by treatment with BBr3 in a manner as previously described for example 1d to give 219 mg (51%) of a pale orange solid. 1H NMR (CD3OD) δ7.75 (1H, d, J=8.5 Hz), 7.47 (1H, s), 6.61-6.66 (2H, m), 3.62 (3H, s), 3.24 (1H, s), 2.79 (3H, s). ESIMS (MH+): 205.10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06869962B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-ea232dacefcb428d8d5f29a93728cdad |
| Source note | uspto-grants-2005_03 |