反应详情

This material was prepared by the reaction of 7-chloro-2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridine 1e with 6-hydroxy-1-methyl-1H-indole-3-carboxylic acid methylamide 21b and Cs2CO3 in a manner as previously described for example 1. 1H NMR (300 MHz, CDCl3) δ8.43 (1H, d, J=5.5 Hz), 8.05 (1H, d, J=8.7 Hz), 7.67 (1H, s), 7.61 (1H, s), 7.17 (1H, d, J=2.1 Hz), 7.13 (1H, s), 7.08 (1H, dd, J=2.1, 8.7 Hz), 7.02 (1H, s), 6.54 (1H, d, J=5.5 Hz), 3.95 (3H, s), 3.75 (3H, s), 3.01 (3H, s). LCMS (ESI+) [M+H]/z Calc'd 418, found 418. Anal. (C22H19N5O2S.0.25EtOAc) C, H, N.