Cesium carbonate → HCID 20767830, compound

Participants

Role	Name	HCID	Charge
Reactant	Cesium carbonate	HCID 10796	—
Reactant	6-hydroxy-N,1,2-trimethyl-1H-indole-3-carboxamide	HCID 22143530	—
Reactant	7-Chloro-2-[3-hydroxyazetidin-1-carbonyl]thieno[3,2-b]pyridine	HCID 22143591	—
Product	HCID 20767830	HCID 20767830	—

Reaction Steps

This material was prepared by the reaction of (7-chloro-thieno [3,2-b]pyridin-2-yl)-(3-hydroxy-azetidin-1-yl)-methanone 9d with 6-hydroxy-1,2-dimethyl-1H-indole-3-carboxylic acid methylamide 16e and Cs2CO3 in a manner as previously described for example 1. 1H NMR (300 MHz, CD3OD) δ8.41 (1H, d, J=5.5 Hz), 7.78-7.74 (2H, m), 7.29 (1H, d, J=2.1 Hz), 6.95 (1H, dd, J=2.1, 8.6 Hz), 6.62 (1H, d, J=5.5 Hz), 4.76-4.73 (2H, m), 4.63 (1H, bs), 4.35-4.32 (2H, m), 3.97-3.94 (1H, m), 3.62 (3H, s), 2.89 (3H, s), 2.57 (3H, s). LCMS (ESI+) [M+H]/z Calc'd 451, found 451.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06869962B2
Source dataset	uspto-grants-2005_03
ORD ID	ord-219764f25de14550811e3f06bae4d3a8
Source note	uspto-grants-2005_03