Dimethylamine → 7-Chloro-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide

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Reaction Steps

This material was prepared from 7-chlorothieno[3,2-b]pyridine-2-carboxylic acid (0.57 g, 2.67 mmole), SOCl2 (5 ml), 2.0 M N,N-dimethylamine in THF (1.60 ml, 3.20 mmole) and Et3N (0.447 ml, 3.20 mmole) in a manner as previously described for example 9d to give a brown solid (0.54 g, 84%). 1H NMR (300 MHz, CDCl3) δδδ1H, d, J=5.0 Hz), 7.74 (1H, s), 7.35 (1H, d, J=5.0 Hz), 3.28 (3H, s), 3.22 (3H, s); ESIMS (MH+): 240.95.

Provenance & Evidence