6-Bromopyridine-2-carbaldehyde → HCID 22143597, compound

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Reaction Steps

This material was prepared by coupling 7-chloro-2-(trimethylstannyl)thieno[3,2-b]pyridine 39a (0.707 g, 2.17 mmole) with 6-bromopyridine-2-carbaldehyde (0.396 g, 2.17 mmole) using tereakis (triphenylphosphine) palladium(0) (100 mg) as catalyst in a manner as previously described for example 39b to give a white solid (0.161 g, 27%). 1H NMR (300 MHz, CDCl3) δ10.15 (1H, s), 8.61 (1H, d, J=5.1 Hz), 7.93-8.09 (4H, m) 7.31 (1H, d, J=5.1 Hz); ESIMS (MH+): 275.00.

Provenance & Evidence