HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-chloro-6-hydroxy-N,1-dimethyl-1H-indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 2-chloro-6-methoxy-N,1-dimethyl-1H-indole-3-carboxamide | HCID 22143553 | — |
| Product | 2-chloro-6-hydroxy-N,1-dimethyl-1H-indole-3-carboxamide | HCID 22143680 | 85% |
Reaction Steps
This material was prepared by reaction of 2-chloro-6-methoxy-N,1-dimethyl-1H-indole-3-carboxamide 75b (0.38 g, 1.4 mmole) with 1.0 M BBr3 in CH2Cl2 (4.19 ml, 4.19 mmole) in a manner as previously described for example 1d to give an off-white solid (0.195 g, 85%). 1NMR (300 MHz, CD3OD) δ7.61 (1H, d, J=8.3 Hz), 6.65 (1H, s), 6.62 (1H, d, J=2.1 Hz), 3.56 (3H, s) 2.85 (3H, s); ESIMS (MH+): 239.00.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06869962B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-edf831f6ff134c64b8a4bfa4949248d8 |
| Source note | uspto-grants-2005_03 |