Isopropylamine → 6-Methoxy-2-methylbenzofuran-3-carboxylic acid isopropylamide

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Reaction Steps

This material was prepared from 6-methoxy-2-methylbenzofuran 12a (500 mg, 3.1 mmole) by acylation with oxalyl chloride in the presence of AlCl3, followed by treatment with isopropylamine in a manner as previously described for example1c to give 540 mg (71%) of an off-white solid. 1H NMR (DMSO-d6) δ7.80 (1H, d, J=7.8 Hz), 7.50 (1H, d, J=8.6 Hz), 7.14 (1H, d, J=2.2 Hz), 6.89 (1H, dd, J=8.6, 2.2 Hz), 4.09 (1H, m), 3.76 (3H, s), 2.56 (3H, s), 1.16 (6H, d, J=6.6 Hz).

Provenance & Evidence