HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 6-Hydroxy-2-methyl-benzofuran-3-carboxylic acid isobutyl amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 6Methoxy-2-methyl-benzofuran-3-carboxylic acid isobutyl-amide | HCID 20767928 | — |
| Product | 6-Hydroxy-2-methyl-benzofuran-3-carboxylic acid isobutyl amide | HCID 20767865 | — |
Reaction Steps
This material was prepared from 6-methoxy-2-methyl-benzofuran-3-carboxylic acid isobutyl amide 84a by treatment with BBr3 in a manner as previously described for example 1d. 1H NMR (DMSO-d6) δ9.53 (1H, s), 7.90 (1H, t, J=6.1 Hz), 7.44 (1H, d, J=8.3 Hz), 6.86 (1H, s), 6.74 (1H, dd, J=8.6, 1.8 Hz), 3.07 (2H, t, J=6.1 Hz), 2.52 (3H, s), 1.81 (1H, m). 0.90 (6H, d, J=6.8 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06869962B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-39452710a41a45099874633b866cfc50 |
| Source note | uspto-grants-2005_03 |