HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 6-hydroxy-2-methylbenzofuran-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 2-Methylbenzofuran-6-yl acetate | HCID 22143556 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 6-hydroxy-2-methylbenzofuran-3-carboxylate | HCID 22143518 | 69% |
Reaction Steps
This material was prepared from 6-acetoxy-2-methylbenzofuran 89b (0.81 g, 4.3 mmole) by acylation with oxalyl chloride in the presence of AlCl3, followed by treatment with methanol and K2CO3 in a manner as previously described for example 11a to give a beige solid (607 mg, 69%). 1H NMR (DMSO-d6) δ9.64 (1H, s), 7.62 (1H, d, J=8.5 Hz), 6.93 (1H, d, J=1.9 Hz), 6.78 (1H, dd, J=8.5, 2.0 Hz), 3.79 (3H, s), 2.66 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06869962B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-b7d74162077f4feb88dd46ed041abf6c |
| Source note | uspto-grants-2005_03 |