反应详情

This material was prepared from the reaction of 6-hydroxy-2-methylbenzo[b]thiophene-3-carboxylate 11a (267 mg, 1.20 mmole) with 7-chloro-2-{[(3R)-3-methoxypyrrolidin-1-yl]carbonyl}thieno[3,2-b]pyridine 4b (297 mg, 1.00 mmole) and Cs2CO3 (977 mg, 3.00 mmole) in a manner similar to that previously described for example 1 to give a brown solid (480 mg, 100%). 1H NMR (DMSO-d6, 300 MHz) δ8.58 (1H, d, J=5.46 Hz), 8.39 (1H, d, J=8.85 Hz), 8.07 (1H, s), 8.02 (1H, d, J=2.26 Hz), 7.42 (1H, dd, J=2.35, 8.95 Hz), 6.79 (1H, d, J=5.46 Hz), 4.12-3.80 (3H, m), 3.91 (3H, s), 3.68-3.46 (2H, m), 3.27, 3.24 (3H, s), 2.82 (3H, s), 2.17-1.92 (2H, m).