Sodium borohydride → HCID 22506963, compound

HRID 985410Notes

Reaction equation

HRID 985410 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:20])[CH2:9][S:10]([C:13]2[CH:14]=[CH:15][C:16](=[O:19])[NH:17][N:18]=2)(=[O:12])=[O:11])=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:20])[CH2:9][S:10]([C:13]2[CH:14]=[CH:15][C:16](=[O:19])[NH:17][N:18]=2)(=[O:12])=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 22506968HCID 22506968, compound

Product 1

HCID 22506963HCID 22506963, compoundYield 69.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension was prepared of 6-[2-(4-chloro-phenyl)-2-oxo-ethanesulfonyl]-2H-pyridazin-3-one (1.0 mmol, 312 mg) prepared according to Example 18 in methanol (10 mL). Sodium borohydride (1.5 mmol, 55 mg) was added to the suspension at room temperature and stirred for 1 hour. The reaction mixture was evaporated and the residue was triturated with 10% hydrochloric acid (5 mL). The resulting white precipitate was filtered and air-dried to afford the title compound (69%, 218 mg); mp, 178-179° C.

Workup

  1. customprepared
  2. customThe reaction mixture was evaporated
  3. customthe residue was triturated with 10% hydrochloric acid (5 mL)
  4. filtrationThe resulting white precipitate was filtered
  5. customair-dried

Sources & evidence

ORD record
ord-c447d8bd9d5a49fbaeb9a2f021518856
Source dataset
uspto-grants-2005_03
Patent number
US06872722B2

Reaction notes

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