(1-methyl-1H-1,2,4-triazol-5-yl)methanol → HCID 22506925, compound

Participants

Reaction Steps

This compound was prepared using the procedure described in example 7, step e, using (2-methyl-2H-[1,2,4]triazol-3-yl)methanol (prepared as described in EP-A-170073) instead of (2-ethyl-2H-[1,2,4]triazol-3-yl)methanol, and using toluene-4-sulfonic acid 3-(2-fluorophenyl)-4-methyl-7-(pyrazin-2-yl)pyrazolo[1,5-d][1,2,4]triazin-2-yl ester instead of toluene-4-sulfonic acid 3-tert-butyl-7-(2,6-difluorophenyl)-4-methylpyrazolo[1,5-d][1,2,4]triazin-2-yl ester. Data for the title compound: 1H NMR (400 MHz, CDCl3) δ 2.54 (3H, s), 3.84 (3H, s), 5.54 (1H, d, J=13 Hz), 5.58 (1H, d, J=13 Hz), 7.21 (1H, m), 7.26 (1H, m), 7.36 (1H, td, J=7.4, 1.8 Hz), 7.46 (1H, m), 7.84 (1H, s), 8.85 (2H, m), 9.48 (1H, d, J=1.4 Hz); MS (ES+) m/e 418 [MH]+. Anal. Found C, 57.37; H, 3.73; N, 28.99%. C20H16FN9O.0.3 H2O.0.07 C6H14 requires C, 57.19; H, 4.13; N, 29.40%.

Provenance & Evidence