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6-Chloropyridine-3-carbaldehyde → 2-(Chloropyrid-5-yl)-(4-chlorophenyl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Chloropyridine-3-carbaldehyde | HCID 2764053 | — |
| 反応物 | 2-(Chloropyrid-5-yl)-(4-chlorophenyl)bromomethane | HCID 22506785 | — |
| 反応物 | HCID 178478191 | HCID 178478191 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(Chloropyrid-5-yl)-(4-chlorophenyl)methanol | HCID 22506792 | — |
反応手順
2-(Chloropyrid-5-yl)-(4-chlorophenyl)bromomethane may be prepared by carrying out the procedure in a manner similar to Example 84, starting with 22.5 cm3 of 4-chlorophenylmagnesium bromide (1 M solution in ethyl ether) in 30 cm3 of tetrahydrofuran, under an inert argon atmosphere, and 2.9 g of 2-chloropyridine-5-carboxaldehyde in 30 cm3 of tetrahydrofuran. 3.42 g of 2-(chloropyrid-5-yl)-(4-chlorophenyl)methanol are thus obtained in the form of a pale green powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06872717B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-8ab2a1aa1016411cbbf3383a214f78fc |
| 出典メモ | uspto-grants-2005_03 |