HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | ethyl 2-{6-[(tert-butoxy)-N-methylcarbonylamino]-2-pyridyl}acetate | HCID 22507075 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 2-(6-(methylamino)pyridin-2-yl)acetate | HCID 22507068 | 100% |
Reaction Steps
To a solution of ethyl 2-{6-[(tert-butoxy)-N-methylcarbonylamino]-2-pyridyl}acetate (3.56 g, 12.1 mmol) in dichloromethane (15 ml) was added trifluoroacetic acid (8 ml). The reaction was stirred for 16 h. The solvent was removed under vacuum and the crude product was chromatographed over silica gel to yield 2.2 g (100%) of Ethyl 2-[6-(methylamino)-2-pyridyl]acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872730B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-fe756ca3d2c144cfbc76617fb511544d |
| Source note | uspto-grants-2005_03 |