3-[3-(Pyridin-3-yl)phenyl]imidazo[1,2-alpha]pyridine-7-carboxaldehyde → 3-[3-(Pyridin-3-yl)phenyl]imidazo[1,2-alpha]pyridine-7-carboxaldehyde O-(2-hydroxyethyl)oxime

Participants

Reaction Steps

The title compound was prepared in a similar manner to that described in Example 14 using O-(2-hydroxyethyl)hydroxylamine hydrochloride and 3-[3-(pyridin-3-yl)phenyl]imidazo[1,2-α]pyridine-7-carboxaldehyde to afford a white crystalline solid, essentially as a single geometric isomer, m.p. 149-151° C. 1H NMR (400 MHz, CDCl3) δH 2.20 (1H, br s), 3.93-3.97 (2H, m), 4.32-4.36 (2H, m), 7.28 (1H, dd, J 2 and 7), 7.37-7.44 (1H, m), 7.58-7.68 (4H, m), 7.75 (1H, s), 7.80 (1H, s), 7.90-7.95 (1H, m), 8.17 (1H, s), 8.31 (1H, d, J 7), 8.63-8.67 (1H, m), 8.90 (1H, s); m/z (ES+) 359 (M++H).

Provenance & Evidence