HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorothiophenol → HCID 22034364, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorothiophenol | HCID 67789 | — |
| Reactant | Bis(trifluoroacetoxy)iodobenzene | HCID 102317 | — |
| Reactant | HCID 11333276 | HCID 11333276 | — |
| Solvent | 1,1,1,3,3,3-Hexafluoro-2-propanol | HCID 13529 | — |
| Product | HCID 22034364 | HCID 22034364 | 43.2% |
Reaction Steps
A solution of 6-methanesulfonyl-2-methyl-1H-indole (207 mg, 1 mmol) in 6 mL of hexafluoroisopropanol was treated with 4-fluorothiophenol (2 mmol) followed by addition of PIFA (1.5 mmol). The dark colored solution was stirred for 30 minutes followed by partitioning between EtOAc and water. Purification by TLC (2:1 hexane/EtOAc) afforded 145 mg of 3-(4-fluoro-phenylsulfanyl)-6-methanesulfonyl-2-methyl-1H-indole, 101, MS: 336 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872744B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-cb5a9fa158884cfd8b6d092a83759f79 |
| Source note | uspto-grants-2005_03 |