Phosphorus tribromide → HCID 22506826, compound

Participants

Reaction Steps

To a solution of 3-methyl-6-(1-methylethyl)-2-methoxybenzyl alcohol (15.9 g, 80 mmol) in THF (160 ml) was added phosphorus tribromide (3.80 ml, 40 mmol) at 0° C. and the mixture was stirred at room temperature for 2 hours. The reaction mixture was washed with saturated brine, dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4) to obtain 21.7 g of the title compound as an oil.

Provenance & Evidence