HCID 86589079, compound → HCID 51360252, compound

HRID 985630Notes

Reaction equation

HRID 985630 reaction equation
[N:1]([CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:25]=[CH:24][C:14]([NH:15]C(=O)C3C=CC=CC=3)=[N:13][C:11]2=[O:12])[C@H:7]([OH:26])[C@@H:6]1[OH:27])=[N+]=[N-]>N>[NH2:1][CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:25]=[CH:24][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[C@H:7]([OH:26])[C@@H:6]1[OH:27]

Participants

3

Reactant 1

HCID 86589079HCID 86589079, compound

Product 1

HCID 51360252HCID 51360252, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

Then, the thus-obtained 5′-amino-5′-deoxy-N4-benzoylcytidine (8.5 g, 24.5 mmol) was dissolved in 28% aqueous ammonia (200 ml), and the mixture was stirred at room temperature for 24 hours. The solution was evaporated to dryness, and acetone was added to recover 5′-amino-5′-deoxycytidine (5.76 g, yield 97%).

Workup

  1. customThe solution was evaporated to dryness, and acetone
  2. additionwas added

Sources & evidence

ORD record
ord-50356b842ae44e948c3349d5689b5f92
Source dataset
uspto-grants-2005_03
Patent number
US06872809B2

Reaction notes

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